Sumo2+3 Rabbit pAb (一抗) | Bioss
货号：bs-7338R
产品详情
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常见问题
概述
产品编号
bs-7338R
产品类型
模式动物抗体、农牧业/家禽抗体
英文名称
Sumo2+3 Rabbit pAb
中文名称
泛素样蛋白Sumo2/3抗体
英文别名
SUMO2_BOVIN; SUMO2; SUMO-2; Ubiquitin-like protein SMT3B (Smt3B); SMT3B; SUMO3_HUMAN; SUMO3; SUMO-3; SMT3 homolog 1; Ubiquitin-like protein SMT3A (Smt3A); SMT3A; SMT3H1; SUMO2_HUMAN; HSMT3; SMT3 homolog 2; Sentrin-2; SMT3H2; SUMO2_MOUSE; SUMO3_MOUSE; SUMO2_PIG; MIF2 suppressor; SUMO2_RAT; SUMO3_RAT; small ubiquitin like modifier 2; SMT3 (suppressor of mif two 3, yeast) homolog 2; SMT3 suppressor of mif two 3 homolog 2 (yeast); SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human Sumo2+Sumo3: 21-95/95
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
10.9+10.5 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, SUMO-2 and SUMO-3, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target proteins. Also, both utilize the E1, E2, and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins to a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis and protein stability. The unconjugated SUMO-1, SUMO-2 and SUMO-3 proteins localize to the nuclear membrane, nuclear bodies and cytoplasm, respectively. SUMO-1 utilizes Ubc9 for conjugation to several target proteins, which include IkBa, MDM2, p53, PML and Ran GAP1. SUMO-2 and SUMO-3 contribute to a greater percentage of protein modification than does SUMO-1, and unlike SUMO-1, they can form polymeric chains. In addition, SUMO-3 regulates b-Amyloid generation and may be critical in the onset or progression of Alzheimer’s disease
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| Flow-Cyt | Human | Mouse, Rat, Rabbit, Cow, Zebrafish, Chicken, Horse | 3ug/test |
交叉反应
交叉反应: Human (predicted: Mouse, Rat, Rabbit, Cow, Zebrafish, Chicken, Horse)
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靶标
基因名
SUMO2
蛋白名
Small ubiquitin-related modifier 2
亚基
Homotrimer (Potential). Crystal packing analysis suggests a possible trimeric assembly, of which the biological significance remains to be determined. Interacts with SAE2 and UBE2I. Covalently attached to a number of proteins. Interacts with PELP1. Interacts with USP25; the interaction sumoylates USP25. Interacts with SIMC1, CASP8AP2, RNF111 AND SOBP (via SIM domains).
亚细胞定位
Nucleus. Nucleus, PML body.
组织特异性
Broadly expressed.
翻译后修饰
Polymeric chains can be formed through Lys-11 cross-linking. Polymeric SUMO2 chains undergo 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination by RNF4.
Cleavage of precursor form by SENP1 or SENP2 is necessary for function.
Cleavage of precursor form by SENP1 or SENP2 is necessary for function.
相似性
Belongs to the ubiquitin family. SUMO subfamily.
Contains 1 ubiquitin-like domain.
Contains 1 ubiquitin-like domain.
功能
Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.
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